Role of Lipids in CNS Regeneration

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This session of “The Lipidomics Webinar” aired on October 25, 2022 . Watch the recording here!


Failure of regeneration capacity limits the restoration of nervous system functionality in demyelinating diseases such as multiple sclerosis. Yet, the responsible mechanisms are only partially understood. I will present data supporting a key role for lipid metabolisms (that is, lipid droplet biogenesis and cholesterol efflux) in phagocytes for regeneration of myelin. Stimulation of the lipid sensing Triggering receptor expressed on myeloid cells or nuclear liver X receptor are possible therapeutic strategies of how to enhance the capacity to regenerate lesioned tissue.


Here is what you can learn

• Lipid metabolism in myelin regeneration

• Lipidomics in molecular neurobiology

• Neuroimmunological processes related to lipids





Dr. Mikael Simons   Professor at TU Munich, DZNE

Mikael Simons is Professor for Molecular Neurobiology at the TU Munich, and Head of Clinical Research & Clinical Trial Unit Munich at the German Centre for Neurodegenerative Diseases in Munich.