FUSION: A web-based application for in-depth exploration of multi-omics data with brightfield histology.

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Significance :

FUSION provides a platform that integrates brightfield histology images of tissue sections

with spatial multi-omics data, enabling researchers to visualize and deeply explore these

high-dimensional datasets, thereby enhancing the understanding of biological processes

within tissues.

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Importance of lipidology :

FUSION can potentially integrate brightfield histology images of tissue sections with spatial

multi-omics data (including lipidomics) in the future. This would allow researchers to observe

how lipid metabolism functions in different cell populations or tissue regions within the spatial

context of the tissue, thereby revealing the spatial distribution and function of lipids in specific

diseases (such as fatty liver disease, tumors, etc.).

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Connectivity to other field :

This paper is closely related to multiple fields, including digital pathology, machine learning,

spatial omics, and precision medicine. The FUSION platform promotes interdisciplinary

collaboration in disease research by integrating histological images with multi-omics data,

advancing the application of pathology, computational biology, and artificial intelligence technologies.

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https://doi.org/10.1101/2024.07.09.602778